After a normalization procedure with ProgenesisQI, which we also previously described, we determined ions estimated to have derived from the eye drop-delivered drugs, as well as the metabolites of these drugs and their additives (Supplementary Table 1)
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Among the key genes implicated in this process are tyrosinase (TYR), tyrosinaserelated protein 1 (TYRP1), tyrosinaserelated protein 2 (TYRP2), microphthalmiaassociated transcription factor (MITF), paired box gene 3 (Pax3), SRYbox transcription factor 10 (Sox10), melanocortin 1 receptor (MC1R), tyrosine kinase receptor (cKit), Plexin C1 (Plexin C1), MelanA (MelanA), premelanosome protein (Pmel17), and the receptor for hepatocyte growth factor (MET)
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