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After roughly four weeks of daily injection, the receptors begin downregulating

Krivic et al., 2008

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Some older studies have evaluated NAD+ at high doses (1-2g daily) for conditions such as chronic schizophrenia, but no improvement was noted in these studies.3 This may be because NAD+ is expected to have poor oral bioavailability.12 For this reason, when trying to boost NAD+ levels using an oral route, precursors such as nicotinamide or nicotinamide mononucleotide are typically used instead of NAD+