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Mitochondrial cascade hypothesis: Mitochondrial dysfunction and the accumulation of reactive oxygen species lead to neuronal damage and ultimately contribute to the pathogenesis of neurodegenerative diseases, particularly AD

This review provides a concise overview of new directions in treatment development for TRD, including treatments targeting the glutamate system, the opioid system, inflammatory signalling systems and others

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Unfortunately, various factors can deplete our glutathione levels, including aging, chronic stress, poor diet, pollution, toxins, and certain medical conditions

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