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Extending any step to 8 weeks instead of 4 significantly reduces GI side effects for most people

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"Retatrutide phase 2 obesity trial outcomes and metabolic effects." Clinical Trial Registry Database

In trial data, people taking retatrutide lost a significant amount of body weight over time

It also competes with NF-B for coactivators required for gene transcription that enhance the activity of transcription factors by facilitating their interactions with the transcriptional machinery