Nat Rev Immunol 12:774785
10.1038/s41467-023-37464-2 139 NortonC
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[DOI] [PubMed] [Google Scholar] 108.Bromfield E., Dworetzky B., Hurwitz S., Eluri Z., Lane L., Replansky S., Mostofsky D
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As depicted in Figure 3, we propose that the lactate-lactylation axis drives PH pathogenesis through five key mechanisms: PASMC proliferation, immune-inflammatory responses, pulmonary fibrosis, abnormal vasoconstriction, and PASMC ferroptosis