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The key structural modification involved designing PT-141 to minimize MC1R activation (responsible for tanning) while preserving MC3R/MC4R effects (responsible for sexual function)

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Oral semaglutide in adults with obesity without diabetes (OASIS 1): A randomized, double-blind, placebo-controlled, phase 3 trial

Dual inhibition of sglt2 and dpp-4 promotes natriuresis and improves glomerular hemodynamic abnorMalities in kk/ta-ins2(Akita) mice with progressive diabetic kidney disease

otherwise these two medications are quite similar in how they work