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7 GLP-1 (pmol/L) Insulin (ng) / DNA (g) Clinical Data Underscores the Critical Role of GLP-1 in PBH and Supports the Potential of GLP-1 Receptor Antagonism as a Targeted Approach Insulin Glucose (mg/dL, mean SEM) Proof of Concept in People (U/mL, mean SEM) with PBH (N=8) Demonstrated: Placebo Placebo 100% prevention of Avexitide Avexitide hypoglycemia NS-Controls NS-Controls Increased the plasma glucose nadir by 70%, matching NS controls Ameliorated hyperinsulinemia Glycemic Rescue Below 50 mg/dL Time (min) Time (min) 8 GLP-1=glucagon-like peptide-1

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For more on timing changes, see can I change my injection day on Zepbound