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doi: 10.1016/j.ccell.2016.09.011 144 JoviiEJJaneAPEichmannTOKorenBrglezVJordanPMet al

Our study has several strengths including the blinding of researchers to experimental groups until data analysis, the use of 16S rRNA gene sequencing to profile the endometrial microbiota of patients with and without endometriosis, the exclusion of people who were using hormone therapies in the 3 months preceding study enrollment, the inclusion of no template negative controls in each PCR run, and the inclusion of patients with surgically confirmed presence or absence of disease

One report of a randomized controlled trial that allocated supplementation with vitamin D to infertile women with PCOS found that supplementation markedly reduced high-sensitivity C-reactive protein (hs-CRP) levels and increased total antioxidant capacity, indicating the potential of vitamin D to mitigate inflammation and oxidative stress in PCOS ( These findings also laid emphasis on how vitamin D influences multiple molecular aspects involved with the pathogenesis of PCOS

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As individuals grow older, glutathione levels drop, and the ability to detoxify free radicals decreases

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