While Zepbound isnt on the VAs standard list of VA-approved medications, it may still be available for long-term weight management through a special request, which requires prior approval from a VA healthcare provider
Choosing natural, whole food alternatives and natural sweeteners is a safer and healthier option if you are looking for some sweetness
Because of this, their shelf life is shorter than brand-name products like Ozempic or Wegovy

Abbreviations: Pla2g6/Phospholipase A2, group VI knockout (a genetic modification where the Pla2g6 gene is knocked out), PASPeriodic Acid-Schiff stain (a staining method used to detect glycogen and other carbohydrates), CD68Cluster of differentiation 68 (a marker for macrophages and monocytes), NeuNNeuronal Nuclei (a neuron-specific nuclear protein), GFAPglial fibrillary acidic protein (a marker for astrocytes), Iba-1Ionized calcium-binding adapter molecule 1 (a marker for microglia), RIP1Receptor-interacting protein 1, RIP3rRceptor-interacting protein 3, -actinBeta-actin (a cytoskeletal protein often used as a loading control in Western blots), PCRPolymerase chain reaction, GLP-1R geneGlucagon-like peptide-1 receptor gene, ATF-3activating transcription Factor 3, BCl2B-cell lymphoma 2 (anti-apoptotic protein), BClxLB-cell lymphoma-extra large (anti-apoptotic protein), BaxBcl-2-associated X protein (pro-apoptotic protein), MPTP1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (a neurotoxin), THTyrosine Hydroxylase (an enzyme involved in dopamine synthesis), 4-HNE4-Hydroxynonenal (a marker of oxidative stress), ATC7Autophagy-related gene 7 (part of the autophagy process), LC2Light chain 2 (part of the autophagy process), Beclin1Bcl-2-interacting myosin-like coiled-coil protein 1, SQSTM1Sequestosome-1 (also known as P62, a protein involved in autophagy), P62Sequestosome-1, -SynAlpha-synuclein (a protein associated with neurodegenerative disorders), LC3Microtubule-associated protein 1A/1B-light chain 3 (part of the autophagy process), GDNFGlial cell-derived neurotrophic Factor, 6-OHDA6-Hydroxydopamine (a neurotoxin), DADopamine, TNF-Tumor necrosis factor-alpha, IL-1Interleukin-1 beta, IRS-1Insulin receptor substrate 1, IRS-1(phospho-S312)Phosphorylated form of IRS-1 at serine 312, GAPDHGlyceraldehyde-3-phosphate dehydrogenase (a common housekeeping gene used as a loading control in experiments), DA5-CHDopamine-5,6-chlorohydroxydihydroxyphenylalanine, ATG7Autophagy-related gene 7, LC3IIMicrotubule-associated protein 1A/1B-light chain 3 (processed form), LC3IMicrotubule-associated protein 1A/1B-light chain 3 isoform I, ROSReactive oxygen species

Key symptoms Persistent feeling of dryness or stickiness in the mouth Thick, stringy saliva Difficulty speaking, chewing, or swallowing Altered taste sensation Cracked lips or sores at the corners of the mouth Increased thirst Potential oral health issues including bad breath and increased risk of dental decay How common is dry mouth with GLP-1 treatments
The transition from 0.5 mg to 1 mg is where many patients notice the 'sweet spot'sufficient appetite suppression to maintain a calorie deficit without overwhelming gastrointestinal effects