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These factors should be taken into consideration in future studies

Estrogen alters the splicing of type 1 corticotropin-releasing hormone receptor in breast cancer cells

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In the setting of gut-derived neuroinflammation, ISR activation robustly promoted transcription of LD biogenesis genes, leading to excessive neutral-lipid accumulation in microglia, whereas pharmacological ISR blockade (with ISRIB) largely reversed the LD burden evoked by inflammatory stimuli, confirming the causal role of ISR in lipotoxic injury

S., Almulla, A