no weight loss on tirzepatide How Does Work for Loss? Semaglutide vs. Tirzepatide for Weight

Medical evidence suggests these effects stem from multiple factors, including hormonal changes, brain reward systems, and physical responses to the medication

Lai Y, et al

Its activity profile is best understood as systems-level polypharmacology rather than single-receptor agonism: published research has documented effects on nitric oxide system signalling, growth-factor receptor expression (including VEGF receptor 2 and growth-hormone receptor), dopamine and serotonin pathway markers, and angiogenic factor regulation

Similarly, the GIPR rs1800437 variant modulates glucose-dependent insulinotropic peptide (GIP) function, which works alongside GLP-1 to regulate hunger and metabolism

Semaglutide essentially gives your body a head start on satiety, so you feel satisfied eating less food

However, fatigue usually goes away over time