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Although basic research should continue to explore the mechanisms of GLP-1RAs in modulating addictive behaviors, human research is needed to examine the safety and efficacy of GLP-1RAs, optimize dosing strategies, and evaluate their utility as part of combination therapies with established pharmacological and behavioral interventions
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Neuropsychopharmacology 45 , 451461 (2020)
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In the STEP-2 study 36 , semaglutide 2.4 mg showed a 6.0% incidence of psychiatric events compared to 3.7% in the placebo group
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