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Graphical Abstract 1 Introduction Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammatory lesions of joint tissues, which display pain, swelling, and decreased function of the affected joints in clinical ( The total glucosides of paeony (TGP) are the effective parts extracted from the dried roots of Paeonia lactiflora Pall (a traditional Chinese herbal medicine), which are mainly consist of monoterpene glycosides, such as paeoniflorin, albiflorin, benzoylpaeoniflorin, oxypaeoniflorin, galloylpaeoniflorin, etc ( Peyers patches (PPs), intraepithelial lymphocytes (IELs), and lamina propria lymphocytes (LPLs) are all key effector sites of the intestinal mucosal immune system

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