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Chronic painand several pain medicationsdisrupt normal sleep architecture, reducing slow-wave and restorative sleep phases

Menke T, Niklowitz P, Reinehr T, de Sousa GJ, Andler W

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Baehring JM, Betensky RA, Batchelor TT

This assertion is further supported by observations in the same cohort of rodents, which indicated a reduction in secondary bile acids alongside an increase in primary BA [165, 170]