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A: Yes, it meets rigorous pharmaceutical-grade specifications, including limits for heavy metals, arsenic, sulfates, and microbial contaminants, making it a safe choice when used as intended in food and supplement products.

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Whilst the medication does not directly affect fluid balance, its gastrointestinal effectsincluding nausea, vomiting, and diarrhoeacan lead to fluid losses requiring conscious replacement

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In this regard, four large randomized, double-blind, placebo controlled trials support the preventive use of topiramate alone for PTD-induced weight gain (53)