This mechanism amplifies existing HGF signaling rather than bypassing it: HGF Potentiation: Dihexa binds to HGF and stabilizes its active conformation, increasing c-Met receptor activation at physiologically relevant HGF concentrations Synaptogenesis: In vitro studies reported that Dihexa promoted new synapse formation at picomolar concentrations orders of magnitude more potent than BDNF in this specific assay Dendritic Spine Formation: Preclinical data suggested increases in dendritic spine density in hippocampal neurons, a structural correlate of learning and memory Oral Bioavailability: Unlike most peptides, Dihexa's small size and peptidomimetic structure may allow oral absorption and blood-brain barrier penetration Cerebrolysin: Multi-Neurotrophic Factor Cocktail Cerebrolysin is a standardized mixture of low-molecular-weight neuropeptides and free amino acids obtained by enzymatic breakdown of porcine brain tissue

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IGF-1 LR3 Reconstitution Reference (1 mg / 1,000 mcg vial) BAC water added 1 mL Concentration 1,000 mcg/mL 20 mcg dose 0.02 mL (2 units) 40 mcg dose 0.04 mL (4 units) 50 mcg dose 0.05 mL (5 units) 80 mcg dose 0.08 mL (8 units) 100 mcg dose 0.10 mL (10 units) BAC water added 2 mL Concentration 500 mcg/mL 20 mcg dose 0.04 mL (4 units) 40 mcg dose 0.08 mL (8 units) 50 mcg dose 0.10 mL (10 units) 80 mcg dose 0.16 mL (16 units) 100 mcg dose 0.20 mL (20 units) BAC water added 3 mL Concentration 333 mcg/mL 20 mcg dose 0.06 mL (6 units) 40 mcg dose 0.12 mL (12 units) 50 mcg dose 0.15 mL (15 units) 80 mcg dose 0.24 mL (24 units) 100 mcg dose 0.30 mL (30 units) Units refer to U-100 insulin syringe markings
Administration of IGF-I down-regulates proteolysis but does not appear to alter protein synthesis (Hussain, Schmitz, Mengel et al., 1994)