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Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner

A multidisciplinary approach involving neuroscience, endocrinology, immunology, nutrition, and computational biology may lead to precision medicine tailored to individual metabolic profiles

By month twelve and beyond, most patients have achieved the majority of their weight loss and shift to maintenance

Estimated mean change in body weight from baseline to week 64 was 13.6% with oral semaglutide 25 mg versus 2.2% with placebo, an estimated difference of 11.4 percentage points

However, the medication's effects on gut motility and the potential for constipation or altered bowel habits could theoretically influence symptoms in patients with pre-existing diverticular disease

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