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However, the effect of GLP-1RAs on hepatic fibrosis seems to be minimal, which is in line with major clinical trials on the effect of liraglutide [49] and semaglutide [50] in patients with NASH

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Individualized dosing, regular laboratory monitoring (particularly IGF-1 levels), and physician oversight are key to maintaining safety and optimizing therapeutic benefit

The SURMOUNT-1 trial evaluating tirzepatide showed more pronounced effects, with participants losing 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) of body weight at 72 weeks

mice, zebrafish, and clawed frogs) the threonine aldolase gene encodes a functional threonine catabolizing enzyme