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TMAO and Acute Coronary Syndrome (ACS) More than half of cardiovascular deaths are caused by ACS, and the main cardiovascular disorder causing these acute cardiovascular events is the development of atherosclerosis (24)

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It also contracts vascular smooth muscle and modulates calcium channels to exacerbate vasoconstriction, increasing cardiac energy expenditure (Restini et al., 2021)

Results showed that both metformin and simvastatin alone were capable of inhibiting cell proliferation