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(2023) Foslevodopa-Foscarbidopa (Vyalev): CADTH Reimbursement Recommendation: Indication: For the treatment of motor fluctuations in patients with advanced levodopa-responsive Parkinsons disease who do not have satisfactory control of severe, debilitating motor fluctuations and hyper-/dyskinesia despite optimized treatment with available combinations of Parkinsons medicinal products

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Additionally, a dose-dependent increase in the B-cell lymphoma 2 (BCL-2)/Bcl-2associated X protein (BAX) was observed, indicating a shift toward cell survival