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ROS production in macrophages triggers the NLRP3 inflammasome 9,33 , but the cellular compartment from which ROS originates remains controversial 34

The latter is then either irreversibly reduced to 5-methylTHF or serves as the one-carbon donor in the synthesis of nucleic acids, where it is required by thymidylate synthetase in the conversion of deoyxuridine to deoxythymidine for pyrimidine biosynthesis or is converted to other folate cofactor forms essential for purine biosynthesis

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Antioxidants like GSH can prevent the harm that glucose and reactive oxygen species cause to -cells

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Its found in lots of common foods, like: Beef