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The end result is an abundance of aggregated non-functional cuproproteins and chaperones alongside depleted intracellular copper stores, resulting in a general lack of cuproenzyme function

At the same time, metformin may also down-regulate the expression of FOXO3 and AKT, and further inhibit the proliferation and invasion ability of glioma stem cells

Author Contributions HL conceived the study

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Growth Hormone Deficiency (GHD) in adults can only be diagnosed using specialized blood tests