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Stay hydrated, especially given potential gastrointestinal effects

It is easiest to break apart your fueling strategy into 60-minute intervals

IGF-1 is a strong stimulator of sebaceous lipogenesis and acne pathogenesis has been linked to elevated IIS with consecutive nuclear FoxO deficiency [16, 17]

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Studies have explored its effects on collagen synthesis, angiogenesis, antioxidant pathways, and modulation of signalling relevant to tissue remodelling

This is reassuring as a starting point but cannot substitute for human safety data, particularly regarding long-term use, drug interactions, and effects in people with underlying conditions