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FIGURE 2 3.3 Metabolic commonalities and differences between the two pneumonia models To compare metabolic features between the models, Venn analysis was conducted to compare the metabolic features between the two pneumonia models, revealing 17 shared differentially abundant metabolites with consistent directional changes in both models (Figures 3A, B)

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Neurons undergoing ferroptosis release damage-associated molecular patterns (DAMPs) such as high-mobility group box-1 protein (HMGB1), ATP, and exosomes enriched in ACSL4-derived metabolites

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