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The article also notes that animal reproduction studies showed fetal harm at doses above therapeutic ranges, while adequate human studies do not exist to confirm risk at clinical doses

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[DOI] [PubMed] [Google Scholar] Ding J., Liu S., Xiao H

Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance

Moreover, in real-world discovery campaigns, a number of additional requirements and constraints govern successful designs