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doi: 10.3389/fpubh.2024.1277113

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The neurons in the affected network compensate for this weak or absent signals by increasing the number of neuro-transmitter receptors

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PFK1 is allosterically activated by 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3(PFKFB3), which converts fructose-6-phosphate (F6P) to fructose-2,6-bisphosphate (F2,6P)