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A 2025 systematic review and network meta-analysis of 55 randomized trials (18,876 participants) demonstrated sustained improvements in HbA1c, fasting glucose, body weight, and systolic blood pressure with GLP-1 RAs for up to 104 weeks, although HbA1c and fasting glucose reductions declined slightly (0.36% and 0.47 mmol/L, respectively) after two years [119]

Restoration of the type I IFN-IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice

Choledocholithiasis: Evaluation, Treatment, and Outcomes

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