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An existing restricted diet or previous deficiency

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Inulin-type fructan intervention restricts the increase in gut microbiome-generated indole in patients with peritoneal dialysis: A randomized crossover study

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IRF1 drives the expression of the transferrin receptor, promotes intracellular Fe2+ accumulation, disrupts iron homeostasis, and induces ferroptosis in cancer cells, while blocking Gln enhances this effect (92)