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Beyond immune exclusion, immune function is actively suppressed by tumors: elevated N- acetylaspartate (NAA) production disrupts the immunological synapse in CD8 + T and NK cells (178), while FGF21 derived from cancer cells rewires cholesterol metabolism toward inducing T-cell exhaustion (155)

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Because SDF-1 activity enhances migration of hematopoietic and endothelial progenitor cells to sites of ischemic injury, DPP4 inhibitors have been employed to enhance tissue healing, most commonly in the setting of myocardial or vascular ischemia

It works by inhibiting plasmin, which can trigger melanin production

An adult with a BMI of 36 and hypertension has an employer plan covering anti-obesity medication

Some providers recommend methenamine hippurate as a non-antibiotic prophylactic option for patients who want to avoid long-term antibiotic use