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Small molecules and hypoxia

A comprehensive approach addressing all contributing factors is typically necessary for optimal outcomes

Gradual tapering produces better outcomes than abrupt discontinuation for the vast majority of people

It is thought to down-regulate inflammatory molecules (cytokines) and up-regulate antioxidant enzymes

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These data suggest that VGF suppression impairs the formation of large aggregates of proglucagon and granin proteins, thereby reducing glucagon granule biogenesis