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The peptide community has accumulated substantial anecdotal experience, but anecdotes are not epidemiology
Science 379 , 127128 (2023)
another advised fasting for 4 to 6 hours before CLN 13
Source: Coskun et al., The Lancet 2022 Phase 2 Results Phase 2 -- Obesity (NEJM 2023) NCT04881760 | Published: New England Journal of Medicine , 2023 (Jastreboff AM, et al.) This was the landmark Phase 2 trial that put retatrutide on the map
Practical strategies for managing digestive tolerance include : Starting with small portions (15g) to assess individual tolerance Choosing plain, air-popped varieties without added fats that may worsen nausea Ensuring adequate fluid intake throughout the day to prevent dehydration Avoiding eating popcorn late in the evening if you experience reflux Keeping a food diary to identify personal trigger foods Contact your GP or prescribing clinician urgently if you experience persistent vomiting, severe abdominal pain, signs of pancreatitis (severe upper abdominal pain radiating to the back), right upper abdominal pain with fever or jaundice (possible gallbladder disease), or inability to maintain adequate hydration
