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Description

Pathologic fusion of the Ewing gene EWS to WT1 (t(11;22)(p13;q12)( EWS/WT1 )) has been shown to abrogate the tumour suppressor function of WT1 and to generate an oncogenic chimeric protein capable of binding and activating the IGF-1R promoter (Karnieli et al, 1996)

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while there is no evidence of harm at that level, caution is advised

Importantly, these side effects are most prominent during treatment initiation and dose escalation periods, with median durations of 8 days for nausea, 3 days for diarrhea, and 2 days for vomiting