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The missing pieces are big: no human dosing, no human pharmacokinetics, no controlled human safety data, and no long-term outcome data in any species

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Notably, studies have also reported an association between low income and decreased odds of SGLT-2 inhibitor treatment, although this relationship was less pronounced than the findings for GLP-1 RAs [16, 22, 24]

Allegations of more adverse effects of the drug have been reported, including ileus, bowel obstructions, gastroparesis , DVT, and PE