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Reviewers have repeatedly noted the need for randomized controlled trials before any therapeutic claim can be supported [12]

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Rebound Hyperpigmentation (Darkening After Stopping) When steroids are discontinued, melanin production rebounds aggressively, causing: Dark patches Uneven skin tone Permanent pigmentation Many people restart the cream to fix thisleading to addiction-like dependency

Efficacy of treatments for orthostatic hypotension: a systematic review