Injected once weekly, it has shown an average of 21% weight loss over 72 weeks when combined with lifestyle changes
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Notably, AmIb had fewer GH29 genes than AmIa and no GH18 genes (Luna et al., 2022), and galactosidase GH110 was hardly expressed in AmIV (Becken et al., 2021)
McConeghy KW, Caffrey AR, Morrill HJ, Trivedi AN, LaPlante KL
For patients without established atherosclerotic CV disease (ASCVD) or chronic kidney disease (CKD) and for whom there is a compelling need to minimize weight gain or promote weight loss, the American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) guidelines recommend GLP-1RA and sodium-glucose co-transporter-2 inhibitor (SGLT2i) drugs as the preferred second-line treatment option for patients with inadequate glycemic control despite use of metformin [1, 9]
Terpstra M, Henry P-G, Gruetter R