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A phase 2 clinical trial published in the New England Journal of Medicine (2023) demonstrated significant body weight reductions in participants with obesity, generating considerable scientific interest

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The primary objective in AWARD-5 was to establish that dulaglutide was noninferior to sitagliptin in its ability to reduce HbA 1c from baseline through 52 weeks

The study addressed two questions: whether the fragment retained activity when delivered enterally rather than parenterally, and whether the effects observed in rodent models translated to human adipose tissue at the cellular level

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Int J Mol Sci 23(2):739 Mezza T, Cinti F, Cefalo CMA, Pontecorvi A, Kulkarni RN, Giaccari A (2019) -cell fate in human insulin resistance and type 2 diabetes: a perspective on islet plasticity