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It is unclear to what extent the reduction in lean mass is attributable to loss of skeletal muscle mass per se, which comprises only one component of total body lean mass in mice, but the lack of effect on fat mass is consistent with the reported paucity of IGF-1Rs on mature adipocytes

These results mirror the clinical trial data

75 , 76 , 77 For example, based on data from a study in Europe and a study in the United States, of people age 6569, the risk of developing dementia by their early to mid80s was 5% to 7% among those with no copies of the e4 form, 15% to 16% among those with one copy, and 31% to 40% among those with two copies

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Numerous studies have looked at this issue, and some have found no benefit at all from cinnamon