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doi: 10.3389/fmicb.2019.02966 43 KoethRALevisonBSCulleyMKBuffaJAWangZGregoryJCet al

The reconstitution process itself is straightforward, but accuracy matters

Irregular eating schedules and sudden reductions in caffeine consumption (often found in high-calorie beverages) are well-established headache triggers that may coincide with GLP-1 treatment

Here we combine cryo-electron microscopy, molecular dynamics simulations, receptor mutagenesis and pharmacological assays, to interrogate the mechanism and consequences of GLP-1R binding to four peptide agonists