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If symptoms last more than a few weeks or become severe, it is advised to see a doctor

Current research extrapolations suggest 1216 week treatment cycles followed by 48 week rest periods, though this is based on precautionary principle rather than evidence of receptor desensitization or tolerance development

On the one hand, part of the conditioning or fitness training is to develop stronger tissues, and having the building blocks of strong ligaments available during this time would make sense

doi: 10.1016/j.freeradbiomed.2004.06.008

Arch Med Res 2020;51:8294

The FDA has raised concerns about certain bodybuilding and performance-enhancement products, including products linked to liver injury, heart attack, stroke, hormone disruption, sexual dysfunction, mood changes, and other serious reactions