Praeklinische Daten deuten darauf hin, dass die duale Rezeptoraktivierung unterschiedliche hypothalamische Neuronenpopulationen rekrutiert, was in Tiermodellen zu additiven Effekten auf die Regulation der Energiehomoeostase fuehrte (Rubino et al., 2021)
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However, meta-analyses incorporating larger cohort studies have demonstrated no significant correlation with elevated pancreatic cancer risk, although the relatively brief duration of these cohort studies may influence these conclusions [25]
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