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Butyrate, in particular, inhibits HDAC3, reduces mTOR activation and glycolysis, enhances macrophage bactericidal activity, and promotes an anti-inflammatory phenotype (92)

A phase 2 trial assessing different doses of bimagrumab (up to 30 mg/kg) in combination with semaglutide as obesity treatment is ongoing (NCT05616013)

Evidence now extends to fatty liver disease, heart failure, and sleep apnea

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