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A list of properties was evaluated, including: molecular weight, number of rotatable bonds, hydrogen bond acceptors, hydrogen bond donors, molar refractivity, topological polar surface area, logarithm of solubility (ESOL), average of the logarithm of the partition coefficient (Consensus), inhibition of the main cytochrome P450 (CYP450) isoforms (1A2, 2C9, 2C19, 2D6, and 3A4), gastrointestinal absorption, bloodbrain barrier permeability and inhibitor or substrate for Pglycoprotein

This may be due to incomplete metabolism of methionine to cysteine as illustrated by the increase in homocysteine levels

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