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CJC-1295 and Somatotroph Biology The GHRH-receptor signalling pathway activated by CJC-1295 stimulates adenylate cyclase, increasing intracellular cAMP and engaging PKA-linked transcriptional regulation of the GH gene in somatotroph cells with in vivo research confirming increased pituitary RNA, GH mRNA, and somatotroph cell number following administration, establishing that GHRH-class secretagogues act on multiple levels of GH axis biology beyond simple acute secretion

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doi:10.2169/internalmedicine.54.2710 McFarland LV, Dublin S

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Hamada Y, Yuki K, Okazaki M, Fujitani W, Matsumoto T, Hashida MK, et al

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