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Layer fluctuating hormones on top of this, and the body loses the buffer it once relied on

Fractionation of TMT-18plex-labeled peptide mixture was performed using an Agilent AdvanceBio Column (2.7 m, 2.1 250 mm) with an Agilent UHPLC 1290 system

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Understanding this is the foundation for understanding why dosing is not a one-size-fits-all figure: the molecule behaves differently from the compounds people often group it with