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Phase 2 clinical trials showed that participants using retatrutide lost 17.5% of their weight after 24 weeks and 24.2% after 48 weeks
Do not inject in the same spot two weeks in a row
Do not apply topical NSAIDs (like Voltaren gel) to injection sites, as they can interfere with medication absorption
In parallel, there is growing focus on small molecule GLP-1R agonists , which have the potential to be administered orally, produced more cost-effectively, and offer improved stability and pharmacokinetic profiles
For example, in March 2023, WW (formerly Weight Watchers) acquired Sequence, a telehealth company that offers prescriptions for obesity drugs, enabling WW to combine its lifestyle and behavioral therapy offers with prescribing GLP-1RAs where appropriate
Clinical trials of GLP-1 drugs have found they can lower inflammation, decrease the risk of cardiovascular and kidney disease and may help cut cravings for alcohol and tobacco
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