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Endocrinology 2006, 147, 47534761

Dichloroacetate Dichloroacetate (DCA), a product of water chlorination, is considered for the treatment of several disorders including genetic mitochondrial diseases and some hyperproliferative conditions 82

Compatible with a wide range of pharmaceuticals

First-line treatment for NAFLD is lifestyle modification to achieve weight reduction, particularly through diet and exercise [6]

Vitamin C and E , which support glutathione recycling

KEY POINTS Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and their clearance by antioxidants