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The rationale cited was allowing time for structural synaptic changes to consolidate between administrations while avoiding potential receptor desensitization

The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88

McGuire FP, Martinez R, Lenz A, Skinner L, Cushman DM

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This is particularly relevant for Long COVID patients dealing with widespread, chronic musculoskeletal pain