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Diminishing returns and more side effects are reported above 150 mg
The earlier phase 3 study tested two doses against placebo, and the results ran the opposite way to intuition: 0.05 mg/kg/day met the primary endpoint (16/35 responders, p=0.007) while the higher 0.10 mg/kg/day dose failed it (8/32, p=0.16) [3]
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B12 is added to the mix because it supports energy production and red blood cell formation
It is a naturally occurring form of the vitamin, it remains in the body for longer than the synthetic cyanocobalamin form, and it is exceptionally well tolerated with an excellent safety profile
Laboratory studies demonstrated: Enhanced fatty acid oxidation in treated animal models Increased plasma glycerol release (an established index of active lipolysis) Elevated mitochondrial fatty acid oxidation capacity Both energy expenditure and fat oxidation increases even without classical -AR pathways The peptide appears to modulate metabolic flexibility in adipocytes
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