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Mice in the experimental group were given 250 or 500 mg/kg VPA solution by gavage daily, and mice in the control group were given an equal volume of saline (5 ml/kg) for 28 days

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When semaglutide has maximally stimulated the GLP-1 pathway, adding GIP receptor activation through tirzepatide provides a genuinely new stimulus that desensitized GLP-1 receptors alone cannot explain away

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