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Addressing inter-individual variability and validating these findings through large-scale, longitudinal human trials will be essential to bridge the gap between preclinical discovery and the realization of disease-modifying therapies in PD

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The 2HG content of experimental samples was determined by interpolation using 2HG peak areas measured in the standards

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This has been achieved through techniques such as peptide sequence modification, peptide lipidation, albumin fusion, and Fc fusion